"Unlike automobiles, jumbo jets cannot run on batteries," notes the Washington Post.

So Friday the White unveiled a plan for "subsidizing sustainable aviation fuels" — which could also give the U.S. a leg up in a brand new industry: Senior White House officials said the program would make the airline industry cleaner while bringing prosperity to rural America. But environmental groups and some scientists expressed reservations about the plan, which would award subsidies based on a scientific model that has previously been used to justify incentives for corn-based ethanol. Studies have found the gasoline additive is exacerbating climate change.

The new tax credits, created through President Biden's signature climate law, are meant to spur production of jet fuels that create no more than half the emissions of the petroleum-based product. Each gallon of such fuel qualifies for a tax credit up to $1.75 per gallon. "The concern is they will end up subsidizing fuels that take an enormous amount of land to produce," said Tim Searchinger, a senior research scholar at Princeton University... Administration officials said on a call with reporters Thursday that they are carefully weighing such concerns. Agencies are in the process of updating the scientific model for gauging climate friendliness of jet fuels, they said, and it will be revised to factor in the emissions impact of cropland converted from food to fuel production. Federal agencies plan to complete their revisions by March 1.

"The sustainable aviation fuel industry is a potential 36 billion gallon industry that for all intents and purposes is just getting started," Agriculture Secretary Tom Vilsack said on the call. "This is a big, big deal."

The U.S. Securities and Exchange Commission on Friday denied a petition by the country's largest crypto exchange, Coinbase Global, seeking new rules from the agency for the digital asset sector. From a report: The five-member body, in a 3-2 vote, said it would not propose new rules because it fundamentally disagreed that current regulations are "unworkable" for the crypto sphere, as Coinbase has argued. The letter marked the latest in a broader tug-of-war between the crypto sector and the top U.S. markets regulator, which has repeatedly said most crypto tokens are securities and subject to its jurisdiction.

The agency has sued several crypto companies, including Coinbase, for listing and trading crypto tokens which it says should be registered as securities. "Existing laws and regulations apply to the crypto securities markets," SEC Chair Gary Gensler said in a separate statement supporting the decision. In 2022, the company pressed the SEC to create a bespoke set of rules for the crypto sector, arguing that existing U.S. securities laws are inadequate. In April, Coinbase appealed to a judge to force the SEC to respond to the petition.

SonicSpike writes: With several asterisks, qualification and caveats, Mickey Mouse in his earliest form will be the leader of the band of characters, films and books that will become public domain as the year turns to 2024. In a moment many close observers thought might never come, at least one version of the quintessential piece of intellectual property and perhaps the most iconic character in American pop culture will be free from Disney's copyright as his first screen release, the 1928 short "Steamboat Willie," featuring both Mickey and Minnie Mouse, becomes available for public use. "This is it. This is Mickey Mouse. This is exciting because it's kind of symbolic," said Jennifer Jenkins, a professor of law and director of Duke's Center for the Study of Public Domain, who writes an annual Jan. 1 column for "Public Domain Day." "I kind of feel like the pipe on the steamboat, like expelling smoke. It's so exciting." U.S. law allows a copyright to be held for 95 years after Congress expanded it several times during Mickey's life.

Scientists are exploring infrasound, low-frequency sound waves produced by tornadoes to develop more accurate early warning systems for these destructive storms. The hope is that eavesdropping on infrasound signals, which travel for hundreds of miles, could provide up to two hours of advance warning. The BBC reports: Scientists have been listening to tornadoes and trying to work out whether they produce a unique sound since the 1970s. Experimental evidence suggests that low-frequency infrasound, with a frequency range of 1-10Hz , is produced while a tornado is taking shape and throughout its life. One recent set of measurements from a tornado near Lakin, Kansas in May 2020 revealed that the twister produced a distinct, elevated signal between 10Hz and 15Hz. In some cases arrays of infrasound detecting microphones have been shown to pick up the noise produced by tornadoes from more than 100km (60 miles) away and have also indicated that the infrasound is produced before tornadogenesis even begins. Researchers hope that by eavesdropping on these noises, it may be possible to not only hear a tornado coming but perhaps even predict them up to two hours before they form.

Since 2020, a team from Oklahoma State University has been testing infrasound's predictive powers using equipment installed in tornado-chasing vehicles. Their portable kit, the Ground-based Local Infrasound Data Acquisition, or "Glinda", system, references a character from The Wizard of Oz. They hope the equipment will help storm chasers to better monitor the development of tornadoes in real time, but requires the equipment to be deployed to the right place at the right time. Some researchers, however, are working on systems that can be left to permanently monitor for tornadoes. One group, led by Roger Waxler, principal scientist at the National Centre for Physical Acoustics (NCPA) based at the University of Mississippi, are planning to deploy four permanent arrays of high-tech sensors in south Mississippi to detect infrasound signals. They hope the system will provide a way of consistently monitoring and detecting tornadoes.

[...] Waxler and his team hope their decade-long experiment will lead to an effective early warning system for tornadoes, particularly when combined with other sources such as doppler radar. "It's not unreasonable that we could localize a tornado to half a football field," adds Waxler. "I envision seeing a map on an app with a dot that shows there's a tornado coming up South Lamar [Avenue, for example]." Warnings have improved in recent decades: from 2003 to 2017, 87% of deadly tornadoes were preceded by an advance warning, but people still have an average of just 10-15 minutes to find shelter. A study based on interviews with 23 survivors of two deadly tornadoes found that people tried to evaluate and respond to the risk of a tornado as the situation evolved, but some did not have a place to shelter easily. Experts believe tornado warnings are too often ignored due to "warning fatigue" created by false alarms and hours of televised storm coverage. One study found 37% of people surveyed did not understand the need for taking precautionary measures during a tornado warning. Waxler hopes that a more accurate early warning system could change the way people respond when they hear a storm is approaching. "Rather than going to hide in your bathtub or cellar, it might be a better idea to get in your car and drive if you know where a tornado is. "The goal is to save lives."

An anonymous reader shares a report: This year has been marked by many terrifying things, but perhaps the most surprising of the 2023 horrors was ... eye drops. The seemingly innocuous teeny squeeze bottle made for alarming headlines numerous times during our current revolution around the sun, with lengthy lists of recalls, startling factory inspections, and ghastly reports of people developing near-untreatable bacterial infections, losing their eyes and vision, and dying.

Recapping this unexpected threat to health, the Food and Drug Administration on Tuesday released an advisory titled "What You Should Know about Eye Drops" in hopes of keeping the dangers of this year from leaking into the next. Among the notable points from the regulator was this stark pronouncement: No one should ever use any homeopathic ophthalmic products, and every single such product should be pulled off the market. The point is unexpected, given that none of the high-profile infections and recalls this year involved homeopathic products. But, it should be welcomed by any advocates of evidence-based medicine.

An anonymous reader quotes a report from REVE News: The U.S. Energy Information Administration (EIA) expects, for the first year on record, combined electricity generation from wind and solar to surpass generation from coal in 2024. EIA expects solar generation in 2024 to increase 39% (228 kilowatthours) from 2023, driven by continued increases in solar capacity. "Renewables, particularly solar photovoltaics, are growing rapidly and making large contributions to electricity generation," DeCarolis said.

EIA expects natural gas prices to be $2.77 per million British thermal units this winter, about 23% lower than previously forecast. The winter season is off to a warmer-than-expected start, so U.S. households are consuming less natural gas for heat than expected. The lower natural gas consumption is also contributing to rising U.S. natural gas inventories, which typically results in lower prices. "We're seeing record domestic natural gas production paired with lower-than-expected natural gas demand, and we expect that is going to push prices lower this winter season," DeCarolis said. EIA will publish its next STEO on January 9, 2024, including the agency's first forecasts for the energy sector through 2025. The full report is available on the EIA website.

David Shepardson reports via Reuters: U.S. Commerce Secretary Gina Raimondo said she expects to make around a dozen semiconductor chips funding awards within the next year, including multi-billion dollar announcements that could drastically reshape U.S. chip production. She announced the first award on Monday -- $35 million to a BAE Systems facility in Hampshire to produce chips for fighter planes from the "Chips for America" semiconductor manufacturing and research subsidy program approved by Congress in August 2022.

"Next year we'll get into some of the bigger ones with leading-edge fabs," Raimondo told reporters. "A year from now I think we will have made 10 or 12 similar announcements, some of them multi-billion dollar announcements." In an interview with Reuters, Raimondo said that the number of awards could go higher than 12. She said she wants the percentage of semiconductors produced in the United States to rise from about 12% to closer to 20% -- though that is still down from 40% in 1990 -- and to have at least two "leading-edge" U.S. manufacturing clusters. In addition, she wants the U.S. to have cutting-edge memory and packaging production and to "meet the military's needs for current and mature" chips. Raimondo noted that the U.S. currently does not have any cutting-edge manufacturing production and wants to get that to about 10%.

Nearly 1 in 5 teenagers in the U.S. say they use YouTube and TikTok "almost constantly," according to a Pew Research Center survey. CNBC reports: The survey showed that YouTube was the most "widely used platform" for U.S.-based teenagers, with 93% of survey respondents saying they regularly use Google's video-streaming service. Of that 93% figure, about 16% of the teenage respondents said they "almost constantly visit or use" YouTube, underscoring the video app's immense popularity with the youth market. TikTok was the second-most popular app, with 63% of teens saying they use the ByteDance-owned short-video service, followed by Snapchat and Meta's Instagram, which had 60% and 59%, respectively. About 17% of the 63% of respondents who said they use TikTok indicated they access the short-video service "almost constantly," the report noted.

Meanwhile, Facebook and Twitter, now known as X, are not as popular with U.S.-based teenagers as they were a decade ago, the Pew Research study detailed. Regarding Facebook in particular, the Pew Research authors wrote that the share of teens who use the Meta-owned social media app "has dropped from 71% in 2014-2015 to 33% today." During the same period, Meta-owned Instagram's usage has not made up the difference in share, increasing from 52% in 2014-15 to a peak of 62% last year, then dropping to 59% in 2023, according to the firm.

Fei-Fei Li and John Etchemendy, the founding co-directors of the Stanford Institute for Human-Centered Artificial Intelligence, in an op-ed on WSJ argue that AI is too important to be left entirely in the hands of the big tech companies: Among other things, 2023 will be remembered as the year artificial intelligence went mainstream. But while Americans from every corner of the country began dabbling with tools like ChatGPT and Midjourney, we believe 2023 is also the year Congress failed to act on what we see as the big picture: AI's impact will be far bigger than the products that companies are releasing at a breakneck pace. AI is a broad, general-purpose technology with profound implications for society that cannot be overstated.

[...] So what needs to happen? President Biden has set the stage, and with all this attention, it's time for Congress to act. They need to pass the Create AI Act, adhere to the elements called on by the new executive order, and invest more in the public sector to ensure America's leadership in creating AI technology steeped in the values we stand for. We also encourage an investment in human capital to bring more talent to the U.S. to work in the field of AI within academia and the government.

But why does this matter? Because this technology isn't just good for optimizing ad revenue for technology companies, but can fuel the next generation of scientific discovery, ranging from nuclear fusion to curing cancer. Furthermore, to truly understand this technology, including its sometimes unpredictable emergent capabilities and behaviors, public-sector researchers urgently need to replicate and examine the under-the-hood architecture of these models. That's why government research labs need to take a larger role in AI. [...]

New York has partnered with chip firms to build $10 billion semiconductor research site at University at Albany, featuring cutting-edge ASML equipment to develop most advanced chips. From a report: Once the machinery is installed, the project and its partners will begin work on next-generation chip manufacturing there, according to New York Gov. Kathy Hochul's office. The partners include tech giant IBM, memory manufacturer Micron and chip manufacturing equipment makers Applied Materials and Tokyo Electron.

The expansion could help New York's bid to be designated a research hub under last year's $53 billion Chips Act. That legislation included $11 billion for a National Semiconductor Technology Center to foster domestic chip research and development. Expanding domestic chip manufacturing and research has become a federal and state-level priority in recent years as concern grows in the U.S. over China's expanding grasp over the industry. Chips are increasingly seen as a crux of geopolitical power, underlying advanced weapons for militaries and sophisticated artificial-intelligence systems.

The White House is racing to overcome internal differences and hash out a new policy over how the US and other governments should view the rapid rise of global data flows that are fueling everything from AI to advanced manufacturing. From a report: In a series of sessions due to begin on Wednesday, President Joe Biden's national security and economic teams are due to meet with companies, labor and human rights advocates, and other experts on the digital economy as part of a review launched last month, according to people directly involved. At issue is laying out a clear US position on the rules for the global internet as governments confront an accelerating amount of data flowing across borders with mounting economic, privacy, income inequality and national security consequences.

Coming just days after the EU agreed late Friday to new regulations for AI, the Biden administration's push highlights how governments are racing to figure out their role in a fast-evolving digital economy and competing to lead the conversation. [...] In an interview, a senior administration official said the US was not backing away from long-standing US advocacy for a free and open internet even as some governments around the world are increasingly trying to restrict information flows.

All those original shows on streaming services brought us "peak TV." But the New York Times reports on the flipside: back in the cable universe, they're experiencing "zombie TV": In 2015, the USA cable network was a force in original programming. Dramas like "Suits," "Mr. Robot" and "Royal Pains" either won awards or attracted big audiences. What a difference a few years make. Viewership is way down, and USA's original programming department is gone. The channel has had just one original scripted show this year, and it is not exclusive to the network — it also airs on another channel. During one 46-hour stretch last week, USA showed repeats of NBC's "Law & Order: Special Victims Unit" for all but two hours, when it showed reruns of CBS' "NCIS" and "NCIS: Los Angeles."

Instead of standing out among its peers, USA is emblematic of cable television's transformation. Many of the most popular channels — TBS, Comedy Central, MTV — have quickly morphed into zombie versions of their former selves. Networks that were once rich with original scripted programming are now vessels for endless marathons of reruns, along with occasional reality shows and live sports... Advertisers have begun to pull money from cable at high rates, analysts say, and leaders at cable providers have started to question what their consumers are paying for. In a dispute with Disney this year, executives who oversee the Spectrum cable service said media companies were letting their cable "programming house burn to the ground...."

The media companies that own the channels are in a bind. The so-called cable bundle was enormously profitable for media companies, and more than 100 million households subscribed at the peak. But subscribers are rapidly declining as people migrate toward streaming. Now roughly 70 million households subscribe to cable. As a result, most media companies are pulling resources from their individual cable networks and directing investment toward their streaming services. Peacock, which is owned by NBCUniversal, also the parent of USA, has begun making more and more original scripted shows over the last three years.

However, most streaming services are hemorrhaging cash. (An NBCUniversal executive said this week that Peacock would lose $2.8 billion this year.) Cable, although it is getting smaller, remains profitable.
Media analyst Michael Nathanson believes last year was saw a "tipping point" when cable advertising decreased — by double-digit percentages — in five consecutive fiscal quarters. "Advertisers are starting to realize that there's really nothing on here and they shouldn't pay for it."

One consultant who works with entertainment companies and used to run marketing at the Oxygen cable network tells the newspaper that cable channels "are being stripped for parts." The article calculates that in 2022 there were 39% fewer scripted programs on basic and premium cable than there were in 2015.

"Reruns are filling the hole."

"Over the years, Austin has seen a huge migration of tech companies moving to the city, from billionaire owners of Twitter (X) to the largest search engine in the world," according to a local news site in Texas.

"But many startups are now choosing to leave the capital city they once flocked to because of the rising cost of living, low funding, and lack of diversity, according to TechCrunch. " On Thursday, December 7, the cloud computing company VMWare announced it was laying off 577 employees in Austin as part of a nationwide job reduction to cut costs, according to the Austin American-Statesman. TechCrunch is reporting that startup founders, like Techstars Managing Director Amos Schwartzfarb, are announcing their decisions to leave Austin's "lackluster" startup scene... In 2022, Meta abandoned plans to move into the biggest skyscraper in Austin, and Google froze plans to move into 35 floors of a different downtown building, despite paying rent to the developer, according to the Washington Post...

In January, CEO Don Ward of Laundris, a B2B enterprise industrial software platform, announced he would be relocating his company to Tulsa because it reminded him "of where Austin was 10 years ago in terms of the tech ecosystem being built," according to Tulsa World. Last month, startup unicorn Cart, an e-commerce business, announced it was moving its headquarters back to Houston after relocating to Austin in late 2021, according to TechCrunch.

"The United States military is preparing to launch its secretive X-37B space plane on a seventh mission in orbit," reports NBC News.

Shaped like a small space shuttle, "It's an itty-bitty spaceplane, not quite 30 feet long and under 10 feet tall," writes the Washington Post, "with a pair of stubby wings and a rounded, bulldog-like nose." Space.com says the launch window for the uncrewed vehicle opens Monday at 8:14 p.m. EST.

From NBC News: For the first time, the X-37B will ride into orbit atop a SpaceX Falcon Heavy rocket. Since its debut more than a decade ago, the X-37B has been a source of intrigue within the space community, mostly owing to the mysterious nature of its activities in low Earth orbit. Despite not knowing its true purpose or location, skywatchers have occasionally spotted and photographed the space plane in the night sky using telescopes... The military is tight-lipped about such operations, but the Space Force said the X-37B missions "are key to ensuring safe and responsible operations in space for all users of the space domain..."
The "U.S. Space Force says that launching on SpaceX's Falcon Heavy rocket will allow testing "in new orbital regimes, experimenting with space domain awareness technologies and investigating the radiation effects to NASA materials."

The Washington Post notes that "The reference about 'space domain awareness' could mean that it will be keeping an eye on other satellites, potentially watching for threats": At least one part of the mission is known. The vehicle will "expose plant seeds to the harsh radiation environment of long-duration spaceflight" in an experiment for NASA. In the past, the Pentagon has also used the X-37B to test some of its cutting edge technologies, including a small solar panel designed to transform solar energy into microwaves, a technology that one day could allow energy harnessed in space to be beamed back to Earth...

If Sunday's X-37B mission is like previous ones, the spaceplane could be in space for a while. Its first flight, which launched in 2010, lasted 224 days.

After billionaire Bill Ackman demanded three college presidents "resign in disgrace," that post on X — excerpting their testimony before a U.S. Congressional committee — has now been viewed more than 104 million times, provoking a variety of reactions.

Saturday afternoon, one of the three college presidents resigned — University of Pennsylvania president Liz Magill.

Politico reports that the Republican-led Committee now "will be investigating Harvard University, MIT and the University of Pennsylvania after their institutions' leaders failed to sufficiently condemn student protests calling for 'Jewish genocide.'" The BBC reports a wealthy UPenn donor reportedly withdrew a stock grant worth $100 million.

But after watching the entire Congressional hearing, New York Times opinion columnist Michelle Goldberg wrote that she'd seen a "more understandable" context: In the questioning before the now-infamous exchange, you can see the trap [Congresswoman Elise] Stefanik laid. "You understand that the use of the term 'intifada' in the context of the Israeli-Arab conflict is indeed a call for violent armed resistance against the state of Israel, including violence against civilians and the genocide of Jews. Are you aware of that?" she asked Claudine Gay of Harvard. Gay responded that such language was "abhorrent."

Stefanik then badgered her to admit that students chanting about intifada were calling for genocide, and asked angrily whether that was against Harvard's code of conduct. "Will admissions offers be rescinded or any disciplinary action be taken against students or applicants who say, 'From the river to the sea' or 'intifada,' advocating for the murder of Jews?" Gay repeated that such "hateful, reckless, offensive speech is personally abhorrent to me," but said action would be taken only "when speech crosses into conduct." So later in the hearing, when Stefanik again started questioning Gay, Kornbluth and Magill about whether it was permissible for students to call for the genocide of the Jews, she was referring, it seemed clear, to common pro-Palestinian rhetoric and trying to get the university presidents to commit to disciplining those who use it. Doing so would be an egregious violation of free speech. After all, even if you're disgusted by slogans like "From the river to the sea, Palestine will be free," their meaning is contested...
Liberal blogger Josh Marshall argues that "While groups like Hamas certainly use the word [intifada] with a strong eliminationist meaning it is simply not the case that the term consistently or usually or mostly refers to genocide. It's just not. Stefanik's basic equation was and is simply false and the university presidents were maladroit enough to fall into her trap."

The Wall Street Journal published an investigation the day after the hearing. A political science professor at the University of California, Berkeley hired a survey firm to poll 250 students across the U.S. from "a variety of backgrounds" — and the results were surprising: A Latino engineering student from a southern university reported "definitely" supporting "from the river to the sea" because "Palestinians and Israelis should live in two separate countries, side by side." Shown on a map of the region that a Palestinian state would stretch from the Jordan River to the Mediterranean Sea, leaving no room for Israel, he downgraded his enthusiasm for the mantra to "probably not." Of the 80 students who saw the map, 75% similarly changed their view... In all, after learning a handful of basic facts about the Middle East, 67.8% of students went from supporting "from the river to the sea" to rejecting the mantra. These students had never seen a map of the Mideast and knew little about the region's geography, history, or demography.
More about the phrase from the Associated Press: Many Palestinian activists say it's a call for peace and equality after 75 years of Israeli statehood and decades-long, open-ended Israeli military rule over millions of Palestinians. Jews hear a clear demand for Israel's destruction... By 2012, it was clear that Hamas had claimed the slogan in its drive to claim land spanning Israel, the Gaza Strip and the West Bank... The phrase also has roots in the Hamas charter... [Since 1997 the U.S. government has considered Hamas a terrorist organization.]

"A Palestine between the river to the sea leaves not a single inch for Israel," read an open letter signed by 30 Jewish news outlets around the world and released on Wednesday... Last month, Vienna police banned a pro-Palestinian demonstration, citing the fact that the phrase "from the river to the sea" was mentioned in invitations and characterizing it as a call to violence. And in Britain, the Labour party issued a temporary punishment to a member of Parliament, Andy McDonald, for using the phrase during a rally at which he called for a stop to bombardment.
As the controversy rages on, Ackman's X timeline now includes an official response reposted from a college that wasn't called to testify — Stanford University: In the context of the national discourse, Stanford unequivocally condemns calls for the genocide of Jews or any peoples. That statement would clearly violate Stanford's Fundamental Standard, the code of conduct for all students at the university.
Ackman also retweeted this response from OpenAI CEO Sam Altman: for a long time i said that antisemitism, particularly on the american left, was not as bad as people claimed. i'd like to just state that i was totally wrong. i still don't understand it, really. or know what to do about it. but it is so fucked.
Wednesday UPenn's president announced they'd immediately consider a new change in policy," in an X post viewed 38.7 million times: For decades under multiple Penn presidents and consistent with most universities, Penn's policies have been guided by the [U.S.] Constitution and the law. In today's world, where we are seeing signs of hate proliferating across our campus and our world in a way not seen in years, these policies need to be clarified and evaluated. Penn must initiate a serious and careful look at our policies, and provost Jackson and I will immediately convene a process to do so. As president, I'm committed to a safe, secure, and supportive environment so all members of our community can thrive. We can and we will get this right. Thank you.
The next day the university's business school called on Magill to resign. And Saturday afternoon, Magill resigned.

15,279 people live in the rural Minnesota town of Bemidji. But now mail carriers there, "overwhelmed by Amazon packages, say they've been warned not to use the word 'Amazon,' including when customers ask why the mail is delayed," reports the Washington Post: "We are not to mention the word 'Amazon' to anyone," said a mail carrier who spoke on the condition of anonymity to protect their job. "If asked, they're to be referred to as 'Delivery Partners' or 'Distributors,'" said a second carrier. "It's ridiculous." The directive, passed down Monday morning from U.S. Postal Service management, comes three weeks after mail carriers in the northern Minnesota town staged a symbolic strike outside the post office, protesting the heavy workloads and long hours caused by the sudden arrival of thousands of Amazon packages...

In addition to being banned from saying "Amazon," postal workers have also been told their jobs could be at risk if they speak publicly about post office issues. Staffers were told they could attend Tuesday's meeting only on their 30-minute lunch break if they changed out of uniform, mail carriers said. One mail carrier said he'd been warned there could be "consequences" for those who showed up.

Postal customers in Bemidji have been complaining about late and missing mail since the beginning of November, when the contract for delivering Amazon packages in town switched from UPS to the post office. Mail carriers told The Post last month that they were instructed to deliver packages before the mail, leaving residents waiting for tax rebates, credit card statements, medical documents and checks...

The post office has held a contract to deliver Amazon packages on Sundays since 2013. The agency, which has lost $6.5 billion in the past year, has said that it's crucial to increase package volume by cutting deals with Amazon and other retailers.
Tuesday the town's mayor held a listening session for the state's two senators with Bemidji residents, whose complaints included "missing medications and late bills resulting in fees." Senator Amy Klobuchar later told the Post that "We need a very clear commitment that we're not going to be prioritizing Amazon packages over regular mail," promising to explore improving postal staffing and pay for rural carriers. On Monday, the Minnesota senators introduced a bill called the Postal Delivery Accountability Act, which would require the post office to improve tracking and reporting of delayed and undelivered mail nationally.

An anonymous reader quotes a report from STAT: The Food and Drug Administration on Friday approved the world's first medicine based on CRISPR gene-editing technology, a groundbreaking treatment for sickle cell disease that delivers a potential cure for people born with the chronic and life-shortening blood disorder. The new medicine, called Casgevy, is made by Vertex Pharmaceuticals and CRISPR Therapeutics. Its authorization is a scientific triumph for the technology that can efficiently and precisely repair DNA mutations -- ushering in a new era of genetic medicines for inherited diseases.

In a clinical trial, Casgevy was shown to eliminate recurrent episodes of debilitating pain caused by sickle cell, which afflicts approximately 100,000 people in the U.S., a vast majority of whom are Black. The therapy, whose scientific name is exa-cel, is described as a potential cure because the genetic fix enabled by CRISPR is designed to last a lifetime, although confirmation will require years of follow-up. The FDA decision comes three weeks after regulators in the U.K. were the first to clear the drug. Approval in the European Union is expected next year. The FDA is also expected to rule on exa-cel as a treatment for beta thalassemia, another inherited blood disorder, by March 30.

The FDA on Friday also approved another sickle cell treatment, a gene therapy from Bluebird Bio called Lyfgenia. Patients will now have the option of two cutting-edge therapies that provide potentially curative benefits. Scientists Emmanuelle Charpentier and Jennifer Doudna published their first CRISPR paper just over a decade ago. In 2020, the research won the pair a Nobel Prize. Reflecting on the approval of Casgevy, Charpentier told STAT via email that she was "excited and pleased" for what it means for patients and their families.

U.S. antitrust regulators told a federal appeals court Wednesday that a federal judge got it wrong when she allowed Microsoft's $69 billion purchase of Activision to close. Reuters reports: Speaking for the Federal Trade Commission, lawyer Imad Abyad argued that the lower-court judge held the agency to too high a standard, effectively requiring it to prove that the deal was anticompetitive. He told a three-judge appeals court panel in California that the FTC had only to show that Microsoft had the ability and incentive to withhold Activision's games from rival game platforms to prove the agency's case. He said the FTC "showed that in the past that's what Microsoft did," referring to allegations that Microsoft made some Zenimax games exclusive after buying that company.

Speaking for Microsoft, lawyer Rakesh Kilaru called the FTC case "weak" and said that the agency had asked the lower-court judge for too much leeway. "It is also clear that the standard can't be as low as the FTC is suggesting," he said. "It can't be kind of a mere scintilla of evidence." He argued that the agency failed to show that Microsoft had an incentive to withhold "Call of Duty" from rival gaming platforms. The judges actively questioned both attorneys, with Judge Daniel Collins pressing the FTC's attorney on how concessions that Microsoft gave British antitrust enforcers affect the U.S. market. He also appeared to take issue with Abyad's assertions that more analysis of the deal was necessary, especially since Microsoft had struck agreements with rivals recently, including one with Sony this past summer. "This was not a rush job on the part of the FTC," he said.

Two antitrust scholars who listened to the arguments said the FTC faced a tough slog to prevail. A finding of "clear error" by a lower court judge is "really stark," said Alden Abbott, a former FTC general counsel, comparing it to the idea that a court ignored key evidence from a witness. Abbott said the appeals court noted that the trial judge had considered "a huge amount of record evidence."

An anonymous reader quotes a report from Motherboard: A high-speed train from the greater Los Angeles area to Las Vegas took a big step closer to reality thanks to a $3 billion federal grant from the Department of Transportation and Joe Biden's signature infrastructure law. The proposed line will be built by Brightline West, a private company owned by Fortress Investment Group. It promises to use all-electric high-speed trains that can travel up to 180 mph, which will half the travel time from Los Angeles to Las Vegas without even taking into account the terrible traffic during peak travel times. The one catch is the LA station will be in Rancho Cucamonga, about 45 miles from Union Station (it is, however, connected via Metrolink trains). The Las Vegas station is more centrally located close to the airport. [...]

Brightline West may be the flashiest rail project in the U.S. at the moment, but it's hardly alone. The U.S. is experiencing a modest but real resurgence in rail expansion thanks to the Bipartisan Infrastructure Law. In addition to Brightline West, a Raleigh-to-Richmond rail corridor received a $1 billion grant to be fit for reliable passenger service, a major boon to a region with good bones for passenger service and high demand that has become neglected and dominated by freight rail. North Carolina is experiencing record passenger rail ridership thanks to more service between Raleigh and Charlotte, two metro areas that have experienced massive population booms in recent decades and desperately need better rail service. The Bipartisan Infrastructure Act is also providing tens of billions of dollars in funding to upgrade Northeast Corridor infrastructure between Washington D.C. and Boston, the nation's busiest rail route. The other California High Speed rail route, the one that a state authority has been trying to build for decades that will only go from Bakersfield to Merced, also received $3 billion in federal funding.

Unidentified governments are surveilling smartphone users via their apps' push notifications, a U.S. senator warned on Wednesday. From a report: In a letter to the Department of Justice, Senator Ron Wyden said foreign officials were demanding the data from Alphabet's Google and Apple. Although details were sparse, the letter lays out yet another path by which governments can track smartphones. Apps of all kinds rely on push notifications to alert smartphone users to incoming messages, breaking news, and other updates. [...] That gives the two companies unique insight into the traffic flowing from those apps to their users, and in turn puts them "in a unique position to facilitate government surveillance of how users are using particular apps," Wyden said.

He asked the Department of Justice to "repeal or modify any policies" that hindered public discussions of push notification spying. In a statement, Apple said that Wyden's letter gave them the opening they needed to share more details with the public about how governments monitored push notifications. "In this case, the federal government prohibited us from sharing any information," the company said in a statement. "Now that this method has become public we are updating our transparency reporting to detail these kinds of requests."