Moderna Says FDA Refuses To Review Its Application for Experimental Flu Shot (cnbc.com) 247
Moderna noted that the agency did not identify any specific safety or efficacy issues with the vaccine, but instead objected to the study design, despite previously approving it. The company added that the move won't impact its 2026 financial guidance. Moderna's jab showed positive phase three data last year, meeting all of the trial goals. At the time, Moderna said the stand-alone flu shot was key to its efforts to advance a combination vaccine targeting both influenza and Covid-19.
Lost Soviet Moon Lander May Have Been Found (nytimes.com) 51
That may soon change. Two research teams think they might have tracked down the long-lost remains of Luna 9. But there's a catch: The teams do not agree on the location. "One of them is wrong," said Anatoly Zak, a space journalist and author who runs RussianSpaceWeb.com and reported on the story last week. The dueling finds highlight a strange fact of the early moon race: The precise resting places of a number of spacecraft that crashed or landed on the moon in the run up to NASA's Apollo missions are lost to obscurity. A newer generation of spacecraft may at last resolve these mysteries.
Luna 9 launched to the moon on Jan. 31, 1966. While a number of spacecraft had crashed into the lunar surface at that stage of the moon race, it was among the earliest to try what rocket engineers call a soft landing. Its core unit, a spherical suite of scientific instruments, was about two feet across. That size makes it difficult to spot from orbit. "Luna 9 is a very, very small vehicle," said Mark Robinson, a geologist at the company Intuitive Machines, which has twice landed spacecraft on the moon.
2 To 3 Cups of Coffee a Day May Reduce Dementia Risk. But Not if It's Decaf. (nytimes.com) 109
People who drank that amount for decades had lower chances of developing dementia than people who drank little or no caffeine, the researchers reported. They followed 131,821 participants for up to 43 years. "This is a very large, rigorous study conducted long term among men and women that shows that drinking two or three cups of coffee per day is associated with reduced risk of dementia," said Aladdin Shadyab, an associate professor of public health and medicine at the University of California, San Diego, who wasn't involved in the study.
The findings, published Monday in JAMA, don't prove caffeine causes these beneficial effects, and it's possible other attributes protected caffeine drinkers' brain health. But independent experts said the study adjusted for many other factors, including health conditions, medication, diet, education, socioeconomic status, family history of dementia, body mass index, smoking and mental illness.
SpaceX Prioritizes Lunar 'Self-Growing City' Over Mars Project, Musk Says (reuters.com) 157
Musk's comments echo a Wall Street Journal report on Friday, stating that SpaceX has told investors it would prioritize going to the moon and attempt a trip to Mars at a later time, targeting March 2027 for an uncrewed lunar landing. As recently as last year, Musk said that he aimed to send an uncrewed mission to Mars by the end of 2026.
National Football League Launches Challenge to Improve Facemasks and Reduce Concussions (cnn.com) 61
Most progress on helmet safety has come from improvements to the shell and padding, helping to reduce the overall rate of concussions. Working with the helmet industry, the league has brought in position-specific helmets, with those for quarterbacks, for example, having more padding in the back after data showed most concussions for QBs came when the back of the head slammed to the turf. But the facemask has mostly remained the same. This past season, 44% of in-game concussions resulted from impact to the player's facemask, up from 29% in 2015, according to data gathered by the NFL. "What we haven't seen over that period of time are any changes of any note to the facemask," [said Jeff Miller, the NFL's executive vice president overseeing player health and safety]... "Now we see, given the changes in our concussion numbers and injuries to players, that as changes are made to the helmet, fewer and fewer concussions are caused by hits to the shell, and more and more concussions as a percentage are by hits to the facemask..."
Selected winners will receive up to $100,000 in aggregate funding, as well as expert development support to help move their concepts from the lab to the playing field.
Winners will be announced in August, according to the article, "and Miller said he expected helmet manufacturers to start implementing any improvements into helmets soon after that."
Scientists Explored Island Cave, Found 1 Million-Year-Old Remnants a Lost World (popularmechanics.com) 5
Trevor Worthy, lead study author and associate professor at Flinders University, said in a statement that "This remarkable find suggests our ancient forests were once home to a diverse group of birds that did not survive the next million years...
"For decades, the extinction of New Zealand's birds was viewed primarily through the lens of human arrival 750 years ago. This study proves that natural forces like super-volcanoes and dramatic climate shifts were already sculpting the unique identity of our wildlife over a million years ago."
Thanks to long-time Slashdot reader fahrbot-bot for sharing the article.
Brookhaven Lab Shuts Down Relativistic Heavy Ion Collider (RHIC) (scientificamerican.com) 28
2002: "There may be a new type of matter according to researchers at Brookhaven National Laboratory."
2010: The hottest man-made temperatures ever achived were a record 4 trillion degree plasma experiment at Brookhaven National Laboratory in New York... anointed the Guinness record holder."
2023: "Scientists at Brookhaven National Laboratory have uncovered an entirely new kind of quantum entanglement."
2026: On Friday, February 6, "a control room full of scientists, administrators and members of the press gathered" at the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Lab in Upton, New York to witness its final collisions, reports Scientific American: The vibe had been wistful, but the crowd broke into applause as Darío Gil, the Under Secretary for Science at the U.S. Department of Energy, pressed a red button to end the collider's quarter-century saga... "I'm really sad" [said Angelika Drees, a BNL accelerator physicist]. "It was such a beautiful experiment and my research home for 27 years. But we're going to put something even better there."
That "something" will be a far more powerful electron-ion collider to further push the frontiers of physics, extend RHIC's legacy and maintain the lab's position as a center of discovery. This successor will be built in part from RHIC's bones, especially from one of its two giant, subterranean storage rings that once held the retiring collider's supply of circulating, near-light speed nuclei...slated for construction over the next decade. [That Electron-Ion Collider, or EIC] will utilize much of RHIC's infrastructure, replacing one of its ion rings with a new ring for cycling electrons. The EIC will use those tiny, fast-flying electrons as tiny knives for slicing open the much larger gold ions. Physicists will get an unrivaled look into the workings of quarks and gluons and yet another chance to grapple with nature's strongest force. "We knew for the EIC to happen, RHIC needed to end," says Wolfram Fischer, who chairs BNL's collider-accelerator department. "It's bittersweet."
EIC will be the first new collider built in the US since RHIC. To some, it signifies the country's reentry into a particle physics landscape it has largely ceded to Europe and Asia over the past two decades. "For at least 10 or 15 years," says Abhay Deshpande, BNL's associate laboratory director for nuclear and particle physics, "this will be the number one place in the world for [young physicists] to come."
The RHIC was able "to separately send two protons colliding with precisely aligned spins — something that, even today, no other experiment has yet matched," the article points out: During its record-breaking 25-year run, RHIC illuminated nature's thorniest force and its most fundamental constituents. It created the heaviest, most elaborate assemblages of antimatter ever seen. It nearly put to rest a decades-long crisis over the proton's spin. And, of course, it brought physicists closer to the big bang than ever before...
When RHIC at last began full operations in 2000, its initial heavy-ion collisions almost immediately pumped out quark-gluon plasma. But demonstrating this beyond a shadow of a doubt proved in some respects more challenging than actually creating the elusive plasma itself, with the case for success strengthening as RHIC's numbers of collisions soared. By 2010 RHIC's scientists were confident enough to declare that the hot soup they'd been studying for a decade was hot and soupy enough to convincingly constitute a quark-gluon plasma. And it was even weirder than they thought. Instead of the gas of quarks and gluons theorists expected, the plasma acted like a swirling liquid unprecedented in nature. It was nearly "perfect," with zero friction, and set a new record for twistiness, or "vorticity." For Paul Mantica, a division director for the Facilities and Project Management Division in the DOE's Office of Nuclear Physics, this was the highlight of RHIC's storied existence. "It was paradigm-changing," he says...
Data from the final run (which began nearly a year ago) has already produced yet another discovery: the first-ever direct evidence of "virtual particles" in RHIC's subatomic puffs of quark-gluon plasma, constituting an unprecedented probe of the quantum vacuum.
RHIC's last run generated hundreds of petabytes of data, the article points out, meaning its final smash "isn't really the end; even when its collisions stop, its science will live on."
But Science News notes RHIC's closure "marks the end for the only particle collider operating in the United States, and the only collider of its kind in the world. Most particle accelerators are unable to steer two particle beams to crash head-on into one another."
Have We Been Thinking About Exercise Wrong for Half a Century? (msn.com) 172
"U.S. and World Health Organization guidelines no longer specify a minimum duration of moderate or vigorous aerobic activity." Movement-tracking studies show even tiny, regular bursts of effort — as short as 30 seconds — can capture many of the health benefits of the gym. Climbing two to three flights of stairs a few times per day could change your life. Experts call it VILPA, or vigorous intermittent lifestyle physical activity. "The message now is that all activity counts," said Martin Gibala, a professor and former chair of the kinesiology department at McMaster University in Canada... Just taking the stairs daily is associated with lower body weight and cutting the risk of stroke and heart disease — the leading (and largely preventable) cause of death globally. While it may not burn many calories (most exercise doesn't), it does appear to extend your health span. Leg power — a measure of explosive muscle strength — was a stronger predictor of brain aging than any lifestyle factors measured in a 2015 study in the journal Gerontology...
How little activity can you do? Four minutes daily. Essentially, a few flights of stairs at a vigorous pace. That's the effort [Emmanuel Stamatakis, a professor of physical activity and population health at the University of Sydney] found delivered significant health benefits in that 2022 study of British non-exercisers. "We saw benefits from the first minute," Stamatakis said. For Americans, the effect is even more dramatic: a 44 percent drop in deaths, according to a peer-reviewed paper recently accepted for publication. "We showed for the first time that vigorous intensity, even if it's done as part of the day-to-day routine, not in a planned and structured manner, works miracles," Stamatakis said. "The key principle here is start with one, two minutes a day. The focus should be on making sure that it's something that you can incorporate into your daily routine. Then you can start thinking about increasing the dose."
Intensity is the most important factor. You won't break a sweat in a brief burst, but you do need to feel it. A highly conditioned athlete might need to sprint to reach vigorous territory. But many people need only to take the stairs. Use your breathing as a guide, Stamatakis said: If you can sing, it's light intensity. If you can speak but not sing, you're entering moderate exertion. If you can't hold a conversation, it's vigorous. The biggest benefits come from moderate to vigorous movement. One minute of incidental vigorous activity prevents premature deaths, heart attacks or strokes as well as about three minutes of moderate activity or 35 to 49 minutes of light activity.
The Bizarre Enhancement Claims Rocking Ski Jumping (nytimes.com) 95
A study published last October in the scientific journal Frontiers found that a 2cm suit change translated to an extra 5.8 metres in jump distance. No specific athletes have been accused. The World Anti-Doping Agency said Thursday it would investigate if presented with evidence, noting its powers extend to banning practices that violate the "spirit of sport." The claims arrive as ski jumping already faces scrutiny -- two Norwegian coaches and an equipment manager received 18-month bans in January for illegally manipulating suit stitching.
NASA Will Finally Let Its Astronauts Bring iPhones To the Moon (x.com) 97
Isaacman framed the move as part of a broader push to challenge what he called bloated qualification requirements, where hardware approvals get mired in radiation characterization, battery thermal tests, outgassing reviews and vibration testing. "That operational urgency will serve NASA well as we pursue the highest-value science and research in orbit and on the lunar surface," he wrote.
Musk Predicts SpaceX Will Launch More AI Compute Per Year Than the Cumulative Total on Earth (substack.com) 245
Solar panels in orbit generate roughly five times the power they do on the ground because there is no day-night cycle, no cloud cover, no atmospheric loss, and no atmosphere-related energy reduction. The system economics are even more favorable because space-based operations eliminate the need for batteries entirely, making the effective cost roughly 10 times cheaper than terrestrial solar, Musk said. The terrestrial bottleneck is already real.
Musk said powering 330,000 Nvidia GB300 chips -- once you account for networking hardware, storage, peak cooling on the hottest day of the year, and reserve margin for generator servicing -- requires roughly a gigawatt at the generation level. Gas turbines are sold out through 2030, and the limiting factor is the casting of turbine vanes and blades, a process handled by just three companies worldwide.
Five years from now, Musk predicted, SpaceX will launch and operate more AI compute annually than the cumulative total on Earth, expecting at least a few hundred gigawatts per year in space. Patel estimated that 100 gigawatts alone would require on the order of 10,000 Starship launches per year, a figure Musk affirmed. SpaceX is gearing up for 10,000 launches a year, Musk said, and possibly 20,000 to 30,000.
Russian Spy Satellites Have Intercepted EU Communications Satellites (arstechnica.com) 85
Russian space vehicles have shadowed European satellites more intensively over the past three years, at a time of high tension between the Kremlin and the West following Moscow's full-scale invasion of Ukraine. For several years, military and civilian space authorities in the West have been tracking the activities of Luch-1 and Luch-2 -- two Russian objects that have carried out repeated suspicious maneuvers in orbit.
Both vehicles have made risky close approaches to some of Europe's most important geostationary satellites, which operate high above the Earth and service the continent, including the UK, as well as large parts of Africa and the Middle East. According to orbital data and ground-based telescopic observations, they have lingered nearby for weeks at a time, particularly over the past three years. Since its launch in 2023, Luch-2 has approached 17 European satellites.
Ultra-Processed Foods Should Be Treated More Like Cigarettes Than Food, Study Says (theguardian.com) 299
UPFs, which are widely available worldwide, are food products that have been industrially manufactured, often using emulsifiers or artificial colouring and flavours. The category includes soft drinks and packaged snacks such as crisps and biscuits. There are similarities in the production processes of UPFs and cigarettes, and in manufacturers' efforts to optimise the "doses" of products and how quickly they act on reward pathways in the body, according to the paper from researchers at Harvard, the University of Michigan and Duke University.
They draw on data from the fields of addiction science, nutrition and public health history to make their comparisons, published on 3 February in the healthcare journal the Milbank Quarterly. The authors suggest that marketing claims on the products, such as being "low fat" or "sugar free," are "health washing" that can stall regulation, akin to the advertising of cigarette filters in the 1950s as protective innovations that "in practice offered little meaningful benefit."
NASA Delays Artemis II To March (nasa.gov) 49
During tanking, engineers spent several hours troubleshooting a liquid hydrogen leak in an interface used to route the cryogenic propellant into the rocket's core stage, putting them behind in the countdown. Attempts to resolve the issue involved stopping the flow of liquid hydrogen into the core stage, allowing the interface to warm up for the seals to reseat, and adjusting the flow of the propellant.
Teams successfully filled all tanks in both the core stage and interim cryogenic propulsion stage before a team of five was sent to the launch pad to finish Orion closeout operations. Engineers conducted a first run at terminal countdown operations during the test, counting down to approximately 5 minutes left in the countdown, before the ground launch sequencer automatically stopped the countdown due to a spike in the liquid hydrogen leak rate.
A Century of Hair Samples Proves Leaded Gas Ban Worked (arstechnica.com) 61
The findings, published in the Proceedings of the National Academy of Sciences, drew on hair collected from Utah residents -- some preserved in family scrapbooks going back generations. Lead levels peaked between 1916 and 1969 at around 100 parts per million, fell to 10 ppm by 1990, and dropped below 1 ppm by 2024. The decline largely tracks the phase-out of leaded gasoline after President Nixon established the EPA in 1970; before the agency acted, most gasolines contained about 2 grams of lead per gallon, releasing nearly 2 pounds of lead per person into the environment each year.
The study arrives amid the Trump administration's broader push to scale back the EPA. Lead regulations have not yet been targeted, but the authors note concerns about loosened enforcement of the 2024 Lead and Copper rule on replacing old lead pipes.
EU Deploys New Government Satcom Program in Sovereignty Push (spacenews.com) 32
SpaceNews notes the new government program GOVSATCOM pools capacity from eight already on-oribit satellites from France, Spain, Italy, Greece and Luxembourg — both national and commercial. And they cite this prediction by EU Defense and Space Commissioner Andrius Kubilius.
The program could expand by 2027. "All member states can now have access to sovereign satellite communications — military and government, secure and resilient, built in Europe, operated in Europe, and under European control," [Kubilius said during his opening remarks at the European Space Conference]... Beginning in 2029, GOVSATCOM is expected to integrate with the 290 satellites in the Infrastructure for Resilience, Interconnectivity and Security by Satellite constellation, known as IRIS2, and be fully operational... "The goal is connectivity and security for all of Europe — guaranteed access for all member states and full European control."
Scientists Create Programmable, Autonomous Robots Smaller Than a Grain of Salt (upenn.edu) 46
The announcement calls them "microscopic swimming machines that can independently sense and respond to their surroundings, operate for months and cost just a penny each." Barely visible to the naked eye, each robot measures about 200 by 300 by 50 micrometers, smaller than a grain of salt. Operating at the scale of many biological microorganisms, the robots could advance medicine by monitoring the health of individual cells and manufacturing by helping construct microscale devices. Powered by light, the robots carry microscopic computers and can be programmed to move in complex patterns, sense local temperatures and adjust their paths accordingly... "We've made autonomous robots 10,000 times smaller," says Marc Miskin, Assistant Professor in Electrical and Systems Engineering at Penn Engineering and the papers' senior author. "That opens up an entirely new scale for programmable robots."
The announcement describes them as "the first truly autonomous, programmable robots at this scale" (as described in two recent academic articles). The team had to design a new propulsion system that utilized the unique locomotion physics in the microscopic realm, according to the university's announcement. So the robots "generate an electrical field that nudges ions in the surrounding solution." Those ions, in turn, push on nearby water molecules, animating the water around the robot's body. "It's as if the robot is in a moving river," says Miskin, "but the robot is also causing the river to move." The robots can adjust the electrical field that causes the effect, allowing them to move in complex patterns and even travel in coordinated groups, much like a school of fish, at speeds of up to one body length per second...
To be truly autonomous, a robot needs a computer to make decisions, electronics to sense its surroundings and control its propulsion, and tiny solar panels to power everything, and all that needs to fit on a chip that is a fraction of a millimeter in size. This is where David Blaauw's team at the University of Michigan came into action... The robots are programmed by pulses of light that also power them. Each robot has a unique address that allows the researchers to load different programs on each robot. "This opens up a host of possibilities," adds Blaauw, "with each robot potentially performing a different role in a larger, joint task."
Thanks to long-time Slashdot reader fahrbot-bot for sharing the news.
Microbes In Space Mutated and Developed a Remarkable Ability (sciencealert.com) 22
The team found that certain space-specific phage mutations were especially effective at killing Earth-bound bacteria responsible for urinary tract infections (UTIs). More than 90 percent of the bacteria responsible for UTIs are antibiotic-resistant, making phage treatments a promising alternative.
Blue Origin Announces Two-Year Pause in Space Tourism - to Focus on the Moon (techcrunch.com) 29
The company said Friday that New Shepard has flown 38 times and carried 98 humans to space, along with more than 200 scientific and research payloads.
"The move is a clear sign that Blue Origin is going all in on its moon program as the company races with rival SpaceX," reports the Business Standard, "to be the first private company to land humans on the lunar surface for Nasa's Artemis program." Blue Origin holds a $3.4 billion contract with Nasa to develop its Blue Moon lander, designed to shuttle astronauts to and from the moon, with a landing originally targeted for 2029... The company is targeting the launch and landing of a cargo version of its lander as soon as this year, as a test ahead of eventually landing humans. Blue Origin has also presented an accelerated plan to Nasa for developing a lander that may be ready for carrying astronauts ahead of Starship, the large new rocket from Elon Musk's SpaceX.